Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

• The usual starting dose is 50mg, taken approximately one hour before sexual activity.
• Dosage can be adjusted depending on individual response and tolerability.
• Take only one tablet in 24 hours, with or without food.
• Avoid grapefruit juice, as it can increase the risk of side effects.
• A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

• Headache
• Flushing
• Nasal congestion
• Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

• Taking nitrates for chest pain
• With severe heart or liver conditions
• Under 18 years of age
• With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

• Nitrates
• Alpha-blockers
• Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

• Generic versions are more affordable than branded Viagra.
• Supplied by licensed UK pharmacies such as Online Chemist.
• Avoid counterfeit products from unregulated websites.

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Disclaimer:

The information on this site is intended for informational purposes only. It is not intended to establish or recommend any medical treatment or diagnosis. Before taking this product, tell your doctor or pharmacist if you're taking or have recently taken any medication. This information is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Drug interactions may change blood pressure and cause side effects. If you think you may have any contraindications, contact your doctor or a pharmacist. This information is not a substitute for medical advice. Talk to your doctor or a pharmacist if you have any questions. This information is for you. Do not take this medication for medical reasons.

Do not take Sildenafil (generic Viagra) if you:

• take any medicines called nitrates, often prescribed for chest pain, or guanylate cyclase stimulators like Adempas (riociguat) for pulmonary hypertension. Your blood pressure could drop to an unsafe level
• are allergic to Sildenafil, or any of the ingredients in Sildenafil

Discuss your health with your doctor to ensure that you are healthy enough for sex. If you experience chest pain, dizziness, or nausea during sex, seek immediate medical help.Sildenafil can cause serious side effects. Rarely reported side effects include:

• an erection that will not go away (priapism). If you have an erection that lasts more than 4 hours, get medical help right away. If it is not treated right away, priapism can permanently damage your penis
• sudden vision loss in one or both eyes. Sudden vision loss in one or both eyes can be a sign of a serious eye problem called non-arteritic anterior ischemic optic neuropathy (NAION). Stop taking Sildenafil and call your healthcare provider right away if you have any sudden vision loss
• sudden hearing decrease or hearing loss. Some people may also have ringing in their ears (tinnitus) or dizziness. If you have these symptoms, stop taking Sildenafil and contact a doctor right away

Before you take Sildenafil, tell your healthcare provider if you:

• have or have had heart problems such as a heart attack, irregular heartbeat, angina, chest pain, narrowing of the aortic valve, or heart failure
• have had heart surgery within the last 6 months
• have pulmonary hypertension
• have had a stroke
• have low blood pressure, or high blood pressure that is not controlled
• have a deformed penis shape
• have had an erection that lasted for more than 4 hours
• have problems with your blood cells such as sickle call anemia, multiple myeloma, or leukemia
• have retinitis pigmentosa, a rare genetic (runs in families) eye disease
• have ever had severe vision loss, including an eye problem called NAION
• have bleeding problems
• have or have had stomach ulcers
• have liver problems
• have kidney problems or are having kidney dialysis have any other medical conditions

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Sildenafil may affect the way other medicines work, and other medicines may affect the way Sildenafil works, causing side effects. Especially tell your healthcare provider if you take any of the following:

• medicines called nitrates
• medicines called guanylate cyclase stimulators such as Adempas (riociguat)
• medicines called alpha-blockers such as Hytrin (terazosin HCl), Flomax (tamsulosin HCl), Cardura (doxazosinmesylate), Minipress (prazosin HCl), Uroxatral (alfuzosin HCl), Jalyn (dutasteride and tamsulosin HCl), or Rapaflo (silodosin). Alpha-blockers are sometimes prescribed for prostate problems or high blood pressure.

Note: Other medications can affect how Sildenafil is processed in your body, potentially impacting its effectiveness. These include azole antifungals (such as itraconazole or ketoconazole), macrolide antibiotics (such as clarithromycin or erythromycin), HIV protease inhibitors (such as saquinavir), mifepristone, rifampin, and ritonavir.

Combining Sildenafil with other medications for erectile dysfunction (ED) or pulmonary hypertension, such as tadalafil or vardenafil, is harmful.

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Dapoxetine+sildenafil is used in the treatment of premature ejaculation and erectile dysfunction in adult men. Premature ejaculation is when a man ejaculates (orgasms) more quickly with less sexual stimulation than the man or his partner would like. This could lead to problems in a sexual relationship. Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity.

Dapoxetine+sildenafil contains Dapoxetine and Sildenafil. Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) that increases the serotonin levels in the brain, thereby increasing the time to ejaculate and improving the control over ejaculation. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor and works by relaxing the blood vessels. It can improve blood flow to the penis and helps to get an erection when sexually stimulated.

You should use this medicine exactly as prescribed by the doctor. The common side-effects of Dapoxetine+sildenafil are dizziness, headache, nausea (feeling sick), stuffy nose, facial flushing (reddening of the face), indigestion, dry mouth, and vision problems such as light sensitivity or blurred vision. These side effects usually resolve without requiring medical attention. However, if any of these side effects persist or get worse, inform your doctor immediately.

It is not recommended to take Dapoxetine+sildenafil if you are allergic to any contents of it. Do not take Dapoxetine+sildenafil if you have severe heart or liver problems, a recent history of heart attack or stroke, hypotension (low blood pressure), eye diseases or vision problems, a history of fainting, and mania or depression. Inform your doctor if you are taking medicines such as nitrates (to treat blood pressure or chest pain), antidepressants, antibiotics, or painkillers. Dapoxetine+sildenafil should not be taken by children and women. It should be used with caution in the elderly. Do not take excessive amounts of alcohol while using Dapoxetine+sildenafil as it may impair the ability of erection and increase the risk of side effects. Dapoxetine+sildenafil may cause dizziness and affect vision, so do not drive or operate heavy machinery if you are not fully alert.

Lakatos M, Wiebel E, Bode E, Buhmer H, Wiebel M, Wiebel J, Rüsdorf K, et al. Erectile dysfunction and premature ejaculation. J Impot Res. 2017;13:17. e47.

Precautionary measures

Keep all your medicines out of the reach of children. Drugs containing nitrates (such as nitroglycerin) should be taken only if advised by your doctor. Other medicines may interact with Dapoxetine+sildenafil. Consult your doctor if you are pregnant or breastfeeding, or if you plan to have sex other than those prescribed for you. Do not take Dapoxetine+sildenafil if you are taking nitrates (such as GTN spray) because they may become combined with Dapoxetine+sildenafil. A special dose and duration of use of Dapoxetine+sildenafil depends on the specific medicine used and the patient’s underlying medical condition. Inform your doctor about all the medicines you take, whether they include Dapoxetine+sildenafil or not.

Indication

This medication is indicated for the treatment of erectile dysfunction (ED). It works only in men and must be used together with a doctor’s prescription to ensure proper balance between safety and efficacy.

Dosage

The recommended dosage of Dapoxetine+sildenafil is one tablet (150 mg) taken before sexual activity and once daily after a 15-30 minutes gap. The doctor may alter the dosage based on personal preference, severity of the condition, age, and other factors. Consult your doctor or pharmacist if any questions persist.

Side effects

On average, men who take this medicine experience mild side- effects at the first sign of ED, although these are usually infrequent. The most common side-effects are headache, indigestion, nasal congestion, nausea, and visual disturbances. These side- effects usually subside, but they may not require medical attention.

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